D-loop dissociation and strand annealing

Stable Identifier
Reaction [transition]
Homo sapiens
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Following repair synthesis, the extended D-loop strands may disassociate from their sister chromatid complements and reanneal with their original complementary strands. A DNA helicase RTEL1 disrupts preformed D-loops and promotes synthesis-dependent strand annealing, yielding non-crossover products and preventing excessive recombination between mitotic sister chromatids (Barber et al. 2008, Uringa et al. 2012).

Literature References
PubMed ID Title Journal Year
18957201 RTEL1 maintains genomic stability by suppressing homologous recombination

West, SC, Collis, SJ, Barber, LJ, Cantor, SB, McIlwraith, MJ, Rose, AM, Martin, JS, Auclair, M, Ward, JD, Tissenbaum, H, O'Neil, NJ, Petalcorin, MI, Youds, JL, Boulton, SJ

Cell 2008
22593209 RTEL1 contributes to DNA replication and repair and telomere maintenance

Zelensky, A, Essers, J, Pickett, HA, Lisaingo, K, Uringa, EJ, Lansdorp, PM, Brind'Amour, J, Rohde, JH

Mol. Biol. Cell 2012
Event Information
Go Biological Process
Catalyst Activity

DNA helicase activity of RTEL1 [nucleoplasm]

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