SRPK1 phosphorylates PRM1 in PRM1:dsDNA

Stable Identifier
R-HSA-9821982
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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SRPK1 phosphorylates PRM1 in PRM1:dsDNA
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In the male pronucleus of the zygote, Serine-arginine-rich protein-specific kinase 1 (SRPK1) phosphorylates protamine 1 (PRM1) on serine-9. This reaction is inferred from mouse homologs in which Srpk1 phosphorylates Prm1 on both serine-9 and serine-43. Human PRM1, however, does not have a serine residue that corresponds to serine-43 of mouse Prm1.
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Output
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as an event of
Catalyst Activity

protein serine kinase activity of SRPK1:Mg2+ [nucleoplasm]

Physical Entity
SRPK1:Mg2+ [nucleoplasm] (Homo sapiens)
Activity
protein serine kinase activity (GO:0106310)
Inferred From
Srpk1 phosphorylates Prm1 in Prm1:dsDNA (Mus musculus)
Authored
May, B  (2022-12-12)
Reviewed
Xie, W  (2023-08-08)
Created
May, B  (2022-12-16)
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