Reactome | Phosphorylation of LIN52 component of MuvB by DYRK1A

Phosphorylation of LIN52 component of MuvB by DYRK1A

Stable Identifier

R-HSA-1362270

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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Phosphorylation of LIN52 component of MuvB by DYRK1A

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LIN52 subunit of MuvB complex is phosphorylated by the protein kinase DYRK1A on the serine residue S28, promoting association of MuvB with p130 (RBL2). From model organism studies, DYRK proteins are known to function in cell cycle regulation, differentiation and stress response.

Literature References

PubMed ID	Title	Journal	Year
21498570	DYRK1A protein kinase promotes quiescence and senescence through DREAM complex assembly DeCaprio, JA, Washburn, MP, Swanson, SK, Florens, LA, Litovchick, L	Genes Dev	2011