Reactome | CCNA:CDK1 phosphorylates HJURP

CCNA:CDK1 phosphorylates HJURP

Stable Identifier

R-HSA-9929884

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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HJURP (Holliday junction recognition protein), a centromeric protein required for the incorporation of newly synthesized CENPA molecules into nucleosomes at replicated centromeres (Foltz et al. 2009, Dunleavy et al. 2009), was identified as a CCNA:CDK2 target in a high-throughput screen (Dumitru et al. 2017). HJURP was shown to be phosphorylated at G2, at least on two CDK consensus sites, S211 and S412, at a time that correlates with high CDK1 activity, and that it binds to CCNA2, and, to a lesser extent, to CCNB (Stankovic et al. 2017). The interaction with CCNA2 is required for the CDK-mediated inhbition of an untimely recruitment of HJURP to the centromere (Stankovic et al. 2017).

Literature References

PubMed ID	Title	Journal	Year
28017591	A Dual Inhibitory Mechanism Sufficient to Maintain Cell-Cycle-Restricted CENP-A Assembly Stankovic, A, Guo, LY, Mata, JF, Bodor, DL, Cao, XJ, Bailey, AO, Shabanowitz, J, Hunt, DF, Garcia, BA, Black, BE, Jansen, LET	Mol Cell	2017
29154753	Cyclin A/Cdk1 modulates Plk1 activity in prometaphase to regulate kinetochore-microtubule attachment stability Dumitru, AMG, Rusin, SF, Clark, AEM, Kettenbach, AN, Compton, DA	Elife	2017