5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus

Stable Identifier
R-HSA-1855230
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus
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In the nucleus, inositol hexakisphosphate kinase 1 (IP6K1) and 2 (IP6K2) phosphorylate5-diphospho-1,3,4,6-tetrakisphosphate (5-PP-IP4) to inositol 1,5-bisdiphospho-3,4,6-trisphosphate (1,5-(PP)2-IP3) (Saiardi et al. 2001, Saiardi et al. 2000, Draskovic et al. 2008).

Literature References
PubMed ID Title Journal Year
10827188 The inositol hexakisphosphate kinase family. Catalytic flexibility and function in yeast vacuole biogenesis

Saiardi, A, Snyder, SH, Caffrey, JJ, Shears, SB

J Biol Chem 2000
18355727 Inositol hexakisphosphate kinase products contain diphosphate and triphosphate groups

Ilc, G, Bhandari, R, Burton, A, Kovacevic, M, Saiardi, A, Podobnik, M, Snyder, SH, Draskovic, P

Chem Biol 2008
11502751 Identification and characterization of a novel inositol hexakisphosphate kinase

Nagata, E, Saiardi, A, Snyder, SH, Snowman, AM, Luo, HR

J Biol Chem 2001
Participants
Input
Output
Participates
as an event of
Catalyst Activity

inositol diphosphate tetrakisphosphate kinase activity of IP6K1/2 [nucleoplasm]

Physical Entity
IP6K1/2 [nucleoplasm] (Homo sapiens)
Activity
inositol diphosphate tetrakisphosphate kinase activity (GO:0052839)
Orthologous Events
5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus (Bos taurus)
5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus (Caenorhabditis elegans)
5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus (Canis familiaris)
5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus (Danio rerio)
5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus (Dictyostelium discoideum)
5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus (Drosophila melanogaster)
5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus (Gallus gallus)
5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus (Mus musculus)
5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus (Plasmodium falciparum)
5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus (Rattus norvegicus)
5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus (Saccharomyces cerevisiae)
5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus (Schizosaccharomyces pombe)
5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus (Sus scrofa)
5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus (Xenopus tropicalis)
Authored
Williams, MG  (2011-10-28)
Reviewed
Wundenberg, T  (2012-11-07)
Created
Williams, MG  (2011-10-28)
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