5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus

Stable Identifier
R-HSA-1855230
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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In the nucleus, inositol hexakisphosphate kinase 1 (IP6K1) and 2 (IP6K2) phosphorylate5-diphospho-1,3,4,6-tetrakisphosphate (5-PP-IP4) to inositol 1,5-bisdiphospho-3,4,6-trisphosphate (1,5-(PP)2-IP3) (Saiardi et al. 2001, Saiardi et al. 2000, Draskovic et al. 2008).
Literature References
PubMed ID Title Journal Year
10827188 The inositol hexakisphosphate kinase family. Catalytic flexibility and function in yeast vacuole biogenesis

Saiardi, A, Snyder, SH, Caffrey, JJ, Shears, SB

J Biol Chem 2000
18355727 Inositol hexakisphosphate kinase products contain diphosphate and triphosphate groups

Ilc, G, Bhandari, R, Burton, A, Kovacevic, M, Saiardi, A, Podobnik, M, Snyder, SH, Draskovic, P

Chem Biol 2008
11502751 Identification and characterization of a novel inositol hexakisphosphate kinase

Nagata, E, Saiardi, A, Snyder, SH, Snowman, AM, Luo, HR

J Biol Chem 2001
Participants
Participates
Catalyst Activity

inositol diphosphate tetrakisphosphate kinase activity of IP6K1/2 [nucleoplasm]

Orthologous Events
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