5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus

Stable Identifier
R-HSA-1855230
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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In the nucleus, inositol hexakisphosphate kinase 1 (IP6K1) and 2 (IP6K2) phosphorylate5-diphospho-1,3,4,6-tetrakisphosphate (5-PP-IP4) to inositol 1,5-bisdiphospho-3,4,6-trisphosphate (1,5-(PP)2-IP3) (Saiardi et al. 2001, Saiardi et al. 2000, Draskovic et al. 2008).

Literature References
PubMed ID Title Journal Year
18355727 Inositol hexakisphosphate kinase products contain diphosphate and triphosphate groups

Draskovic, P, Saiardi, A, Bhandari, R, Burton, A, Ilc, G, Kovacevic, M, Snyder, SH, Podobnik, M

Chem Biol 2008
10827188 The inositol hexakisphosphate kinase family. Catalytic flexibility and function in yeast vacuole biogenesis

Saiardi, A, Caffrey, JJ, Snyder, SH, Shears, SB

J Biol Chem 2000
11502751 Identification and characterization of a novel inositol hexakisphosphate kinase

Saiardi, A, Nagata, E, Luo, HR, Snowman, AM, Snyder, SH

J Biol Chem 2001
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
inositol diphosphate tetrakisphosphate kinase activity of IP6K1/2 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
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