Cyclin E:Cdk2-mediated phosphorylation of Rb

Stable Identifier
R-HSA-188390
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Cyclin E forms a complex with cdk2 and collaborates with the cyclin D-dependent kinases in phosphorylating Rb (Kelly et al.1998, Adams et al.1999).

Literature References
PubMed ID Title Journal Year
9482921 Identification of a substrate-targeting domain in cyclin E necessary for phosphorylation of the retinoblastoma protein

Kelly, BL, Wolfe, KG, Roberts, JM

Proc Natl Acad Sci U S A 1998
9891042 Retinoblastoma protein contains a C-terminal motif that targets it for phosphorylation by cyclin-cdk complexes

Adams, PD, Li, X, Sellers, WR, Baker, KB, Leng, X, Harper, JW, Taya, Y, Kaelin WG, Jr

Mol Cell Biol 1999
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
cyclin-dependent protein serine/threonine kinase activity of Cyclin E:p-T160-CDK2:RB1 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created