Formation of MSH2:MSH6 Complex

Stable Identifier
R-HSA-5444516
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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MSH2 and MSH6 are mismatch DNA repair genes that act together as a heterodimer. The MSH6 subunit is responsible for binding the mismatch, which activates MSH2:MSH6 to exchange ADP for ATP, adopt the conformation to allow movement on the DNA, and interact with downstream effectors.
Literature References
PubMed ID Title Journal Year
8128251 Mutation of a mutL homolog in hereditary colon cancer

Wei, YF, Fleischmann, RD, Papadopoulos, N, Rosen, CA, Haseltine, WA, Nicolaides, NC, Adams, MD, Carter, KC, Ruben, SM, Fraser, CM

Science 1994
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