ATP-dependent release of CDT1 from the OCCM complex

Stable Identifier
R-HSA-9749350
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
ATP-dependent release of CDT1 from the OCCM complex
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Based on studies in budding yeast, once the initial complex of ORC(1-6), CDC6, CDT1 and MCM2-7 (OCCM) is formed, CDT1 is released from DNA in an ATP-dependent manner. The ATPase activity of CDC6 is necessary for CDT1 release, but ATPase activities of other ATPases in the complex (e.g. ORC1) may contribute to CDT1 release. ORC6 is necessary for the retention of MCM2-7 after ATP hydrolysis (Fernández-Cid et al. 2013).

Participants
Input
Output
Participates
as an event of
Catalyst Activity

ATP hydrolysis activity of ORC(1-6):CDC6:origin of replication:CDT1:MCM2-7 [nucleoplasm]

Physical Entity
ORC(1-6):CDC6:origin of replication:CDT1:MCM2-7 [nucleoplasm] (Homo sapiens)
Activity
ATP hydrolysis activity (GO:0016887)
Inferred From
ATP-dependent release of CDT1 from the OCCM complex in budding yeast (Saccharomyces cerevisiae)
Authored
Kusic-Tisma, J  (2021-10-27)
Created
Orlic-Milacic, M  (2021-08-01)
Cite Us!