Reactome | USF1 is phosphorylated by p-MAPK14

USF1 is phosphorylated by p-MAPK14

Stable Identifier

R-HSA-9855910

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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Upstream Stimulatory Factor 1 (USF1) is a transcription factor that binds as a dimer to symmetrical E-box sequences (5'-CACGTG-3'). It has been identified with MITF-M as a regulator of TYR gene expression downstream of UV signaling (Galibert et al, 1998; Galibert et al, 2001; Corre et al, 2004; Corre et al, 2009). MAPK14 (also known as p38 alpha)-dependent phosphorylation of USF1 at residue T153 is promoted by UV stimulation in melanoma cells and enhances DNA-binding at the TYR promoter as assessed by ChIP and EMSA (Galibert et al, 2001).

Literature References

PubMed ID	Title	Journal	Year
9550420	Recognition of the E-C4 element from the C4 complement gene promoter by the upstream stimulatory factor-1 transcription factor Galibert, MD, Boucontet, L, Goding, CR, Meo, T	J Immunol	1997
19389701	Target gene specificity of USF-1 is directed via p38-mediated phosphorylation-dependent acetylation Corre, S, Primot, A, Baron, Y, Le Seyec, J, Goding, C, Galibert, MD	J Biol Chem	2009
15358786	UV-induced expression of key component of the tanning process, the POMC and MC1R genes, is dependent on the p-38-activated upstream stimulating factor-1 (USF-1) Corre, S, Primot, A, Sviderskaya, E, Bennett, DC, Vaulont, S, Goding, CR, Galibert, MD	J Biol Chem	2004
11532965	The Usf-1 transcription factor is a novel target for the stress-responsive p38 kinase and mediates UV-induced Tyrosinase expression Galibert, MD, Carreira, S, Goding, CR	EMBO J	2001