Activated ATM phosphorylates DCLRE1C

Stable Identifier
Reaction [transition]
Homo sapiens
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Activated ATM phosphorylates DCLRE1C (ARTEMIS) at serine residue S645. S645 phosphorylation is necessary for the function of DCLRE1C in non-homologous end joining (NHEJ) (Riballo et al. 2004, Poinsignon et al. 2004, Chen et al. 2005).

Literature References
PubMed ID Title Journal Year
15468306 Phosphorylation of Artemis following irradiation-induced DNA damage

Fischer, A, Soubeyrand, S, de Chasseval, R, Poinsignon, C, Haché, RJ, de Villartay, JP, Moshous, D

Eur. J. Immunol. 2004
15723659 Ataxia-telangiectasia-mutated dependent phosphorylation of Artemis in response to DNA damage

Delia, D, Nakada, S, Mizutani, S, Chessa, L, Minegishi, Y, Lecis, D, Chen, L, Villa, A, Morio, T, Komatsu, K, Nagasawa, M

Cancer Sci. 2005
15574327 A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci

Recio, MJ, Löbrich, M, Kühne, M, Jackson, SP, Parker, AR, Doherty, A, Dahm, K, Rief, N, Riballo, E, Smith, GC, Fricke, A, Gennery, A, Jeggo, PA, Reis, C, Krempler, A

Mol. Cell 2004
Catalyst Activity

protein serine/threonine kinase activity of DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:RIF1:PAX1IP:DCLRE1C [nucleoplasm]

Orthologous Events
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