CDK2 phosphorylates TP53

Stable Identifier
R-HSA-6805109
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
CDK2 phosphorylates TP53
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

CDK2, bound to CCNA (cyclin A), phosphorylates TP53 on serine residue S315 (Luciani et al. 2000).

Literature References
PubMed ID Title Journal Year
10884347 The C-terminal regulatory domain of p53 contains a functional docking site for cyclin A

Luciani, MG, Hutchins, JR, Zheleva, D, Hupp, TR

J. Mol. Biol. 2000
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
cyclin-dependent protein serine/threonine kinase activity of CCNA:p-T160-CDK2 [nucleoplasm]
Physical Entity
CCNA:p-T160-CDK2 [nucleoplasm]
Activity
cyclin-dependent protein serine/threonine kinase activity (0004693)
Orthologous Events
CDK2 phosphorylates TP53 (Bos taurus)
CDK2 phosphorylates TP53 (Danio rerio)
CDK2 phosphorylates TP53 (Mus musculus)
CDK2 phosphorylates TP53 (Rattus norvegicus)
CDK2 phosphorylates TP53 (Sus scrofa)
CDK2 phosphorylates TP53 (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2015-10-14)
Reviewed
Zaccara, S  (2016-02-04)
Inga, A  (2016-02-04)
Created
Orlic-Milacic, M  (2015-10-17)