CDK2 phosphorylates TP53

Stable Identifier
R-HSA-6805109
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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CDK2 phosphorylates TP53
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CDK2, bound to CCNA (cyclin A), phosphorylates TP53 on serine residue S315 (Luciani et al. 2000).

Literature References
PubMed ID Title Journal Year
10884347 The C-terminal regulatory domain of p53 contains a functional docking site for cyclin A

Hutchins, JR, Hupp, TR, Zheleva, D, Luciani, MG

J. Mol. Biol. 2000
Participants
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Output
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as an event of
Catalyst Activity

cyclin-dependent protein serine/threonine kinase activity of CCNA:p-T160-CDK2 [nucleoplasm]

Physical Entity
CCNA:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
Activity
cyclin-dependent protein serine/threonine kinase activity (GO:0004693)
Orthologous Events
CDK2 phosphorylates TP53 (Bos taurus)
CDK2 phosphorylates TP53 (Canis familiaris)
CDK2 phosphorylates TP53 (Danio rerio)
CDK2 phosphorylates TP53 (Drosophila melanogaster)
CDK2 phosphorylates TP53 (Mus musculus)
CDK2 phosphorylates TP53 (Rattus norvegicus)
CDK2 phosphorylates TP53 (Sus scrofa)
Authored
Orlic-Milacic, M  (2015-10-14)
Reviewed
Zaccara, S  (2016-02-04)
Inga, A  (2016-02-04)
Created
Orlic-Milacic, M  (2015-10-17)
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