CDK2 phosphorylates TP53

Stable Identifier
R-HSA-6805109
Type
Reaction
Species
Homo sapiens
Compartment
nucleoplasm
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CDK2 phosphorylates TP53
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CDK2, bound to CCNA (cyclin A), phosphorylates TP53 on serine residue S315 (Luciani et al. 2000).

Literature References
PubMed ID Title Journal Year
10884347 The C-terminal regulatory domain of p53 contains a functional docking site for cyclin A

Hutchins, JR, Hupp, TR, Zheleva, D, Luciani, MG

J. Mol. Biol. 2000
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Catalyst Activity

cyclin-dependent protein serine/threonine kinase activity of CCNA:p-T160-CDK2 [nucleoplasm]

Physical Entity
CCNA:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
Activity
cyclin-dependent protein serine/threonine kinase activity (GO:0004693)
Orthologous Events
CDK2 phosphorylates TP53 (Danio rerio)
CDK2 phosphorylates TP53 (Drosophila melanogaster)
CDK2 phosphorylates TP53 (Mus musculus)
CDK2 phosphorylates TP53 (Rattus norvegicus)
Authored
Orlic-Milacic, M  (2015-10-14)
Reviewed
Zaccara, S  (2016-02-04)
Inga, A  (2016-02-04)
Created
Orlic-Milacic, M  (2015-10-17)
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