Reactome | CDK2 phosphorylates TP53

CDK2 phosphorylates TP53

Stable Identifier

R-HSA-6805109

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Activity through Phosphorylation (Homo sapiens)
        
        CDK2 phosphorylates TP53 (Homo sapiens)

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

CDK2, bound to CCNA (cyclin A), phosphorylates TP53 on serine residue S315 (Luciani et al. 2000).

Literature References

PubMed ID	Title	Journal	Year
10884347	The C-terminal regulatory domain of p53 contains a functional docking site for cyclin A Luciani, MG, Hutchins, JR, Zheleva, D, Hupp, TR	J. Mol. Biol.	2000