CDK5 phosphorylates CLOCK on serine-451 and serine-461

Stable Identifier
R-HSA-9912396
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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CDK5 phosphorylates CLOCK on serine-451 and serine-461
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Cyclin-dependent kinase 5 (CDK5) phosphorylates CLOCK on serine-451 and serine-461 (assayed with mouse Cdk5 and human CLOCK in Kwak et al. 2013). The phosphorylation causes nuclear translocation of CLOCK and increases transcriptional activation by the BMAL1:CLOCK complex (Kwak et al. 2013).
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Output
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as an event of
Catalyst Activity

protein serine/threonine kinase activity of CDK5 [cytosol]

Physical Entity
CDK5 [cytosol] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Inferred From
Cdk5 phosphorylates CLOCK on serine 451 and serine-461 (Homo sapiens)
Authored
May, B  (2024-06-01)
Reviewed
Sancar, A  (2025-02-14)
Albrecht, U  (2025-02-18)
Created
May, B  (2024-06-08)
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