AKT phosphorylates FOXO1A

Stable Identifier
Reaction [transition]
Homo sapiens
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One or more of the isoforms of AKT catalyzes the phosphorylation of FOXO1A protein at three sites, threonine-24, serine-256, and serine-319 (Zhang et al. 2002, 2006). This reaction occurs in the nucleoplasm, and thus is dependent on the phosphorylation and nuclear import of AKT in response to upstream regulatory factors (Burgering and Kops 2002).

Literature References
PubMed ID Title Journal Year
16540465 Kinetic mechanism of AKT/PKB enzyme family

Lofgren, JA, Yamane, H, Wahl, R, Ali, A, Zhang, S, Kendall, RL, Zhang, X

J Biol Chem 2006
12228231 Phosphorylation of serine 256 suppresses transactivation by FKHR (FOXO1) by multiple mechanisms. Direct and indirect effects on nuclear/cytoplasmic shuttling and DNA binding

Unterman, TG, Gan, L, Pan, H, Zhang, X, Adam, S, Guo, S, Mesecar, A, Olson, ST, He, X

J Biol Chem 2002
12114024 Cell cycle and death control: long live Forkheads

Burgering, BM, Kops, GJ

Trends Biochem Sci 2002
Catalyst Activity

protein serine/threonine kinase activity of p-T,p-S-AKT [nucleoplasm]

Orthologous Events
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