AKT phosphorylates FOXO1A

Stable Identifier
R-HSA-211164
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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One or more of the isoforms of AKT catalyzes the phosphorylation of FOXO1A protein at three sites, threonine-24, serine-256, and serine-319 (Zhang et al. 2002, 2006). This reaction occurs in the nucleoplasm, and thus is dependent on the phosphorylation and nuclear import of AKT in response to upstream regulatory factors (Burgering and Kops 2002).

Literature References
PubMed ID Title Journal Year
12228231 Phosphorylation of serine 256 suppresses transactivation by FKHR (FOXO1) by multiple mechanisms. Direct and indirect effects on nuclear/cytoplasmic shuttling and DNA binding

Zhang, X, Gan, L, Pan, H, Guo, S, He, X, Olson, ST, Mesecar, A, Adam, S, Unterman, TG

J Biol Chem 2002
16540465 Kinetic mechanism of AKT/PKB enzyme family

Zhang, X, Zhang, S, Yamane, H, Wahl, R, Ali, A, Lofgren, JA, Kendall, RL

J Biol Chem 2006
12114024 Cell cycle and death control: long live Forkheads

Burgering, BM, Kops, GJ

Trends Biochem Sci 2002
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of p-T,p-S-AKT [nucleoplasm]
Physical Entity
Activity
Orthologous Events
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Reviewed
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