Prkaca phosphorylates Creb1

Stable Identifier
R-NUL-9615367
Type
Reaction [transition]
Species
Rattus norvegicus
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Prkaca phosphorylates Creb1
A recombinant mouse cAMP-dependent protein kinase A, catalytic subunit alpha (Prkaca) (Mellon et al. 1989) phosphorylates in vitro a recombinant rat Creb1 (Gonzales et al. 1989) at a specific residue, serine S133. Phosphorylation of S133 is required for signal-induced transcription in vivo (Gonzalez and Montminy 1989).
Literature References
PubMed ID Title Journal Year
2573431 Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133

Gonzalez, GA, Montminy, MR

Cell 1989
Participants
Input
Output
Catalyst Activity

protein serine/threonine kinase activity of Prkaca [nucleoplasm]

Physical Entity
Prkaca [nucleoplasm] (Mus musculus)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
PKA phosphorylates CREB1 (Homo sapiens)
Authored
Le Novere, N  (2004-03-31)
Jassal, B  (2004-03-31)
Reviewed
Castagnoli, L  (2008-11-06)
Yi, F  (2018-11-02)
Hansen, KB  (2018-11-02)
Created
Orlic-Milacic, M  (2018-08-02)
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