Prkaca phosphorylates Creb1

Stable Identifier
R-NUL-9615367
Type
Reaction [transition]
Species
Rattus norvegicus
Compartment
General
SVG |   | PPTX  | SBGN
Prkaca phosphorylates Creb1

A recombinant mouse cAMP-dependent protein kinase A, catalytic subunit alpha (Prkaca) (Mellon et al. 1989) phosphorylates in vitro a recombinant rat Creb1 (Gonzales et al. 1989) at a specific residue, serine S133. Phosphorylation of S133 is required for signal-induced transcription in vivo (Gonzalez and Montminy 1989).

Literature References
PubMed ID Title Journal Year
2573431 Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133

Gonzalez, GA, Montminy, MR

Cell 1989
Participants
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of Prkaca [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created