Reactome | PTK6 phosphorylates KHDRBS2

PTK6 phosphorylates KHDRBS2

Stable Identifier

R-HSA-8849032

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

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Nuclear PTK6 (BRK) phosphorylates the RNA binding protein KHDRSB2 (SLM1) on an unknown tyrosine residue, thus inhibiting its interaction with RNA. KDRSB2 is a SAM68 (KHDRSB1) family member whose function has been poorly studied (Haegebarth et al. 2004).

Literature References

PubMed ID	Title	Journal	Year
15471878	The nuclear tyrosine kinase BRK/Sik phosphorylates and inhibits the RNA-binding activities of the Sam68-like mammalian proteins SLM-1 and SLM-2 Haegebarth, A, Heap, D, Bie, W, Derry, JJ, Richard, S, Tyner, AL	J. Biol. Chem.	2004