PTK6 phosphorylates KHDRBS2

Stable Identifier
R-HSA-8849032
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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PTK6 phosphorylates KHDRBS2
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Nuclear PTK6 (BRK) phosphorylates the RNA binding protein KHDRSB2 (SLM1) on an unknown tyrosine residue, thus inhibiting its interaction with RNA. KDRSB2 is a SAM68 (KHDRSB1) family member whose function has been poorly studied (Haegebarth et al. 2004).

Literature References
PubMed ID Title Journal Year
15471878 The nuclear tyrosine kinase BRK/Sik phosphorylates and inhibits the RNA-binding activities of the Sam68-like mammalian proteins SLM-1 and SLM-2

Richard, S, Bie, W, Derry, JJ, Haegebarth, A, Heap, D, Tyner, AL

J. Biol. Chem. 2004
Participants
Input
Output
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as an event of
Catalyst Activity

protein tyrosine kinase activity of p-Y342-PTK6 [nucleoplasm]

Physical Entity
p-Y342-PTK6 [nucleoplasm] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Orthologous Events
PTK6 phosphorylates KHDRBS2 (Bos taurus)
PTK6 phosphorylates KHDRBS2 (Danio rerio)
PTK6 phosphorylates KHDRBS2 (Mus musculus)
PTK6 phosphorylates KHDRBS2 (Rattus norvegicus)
PTK6 phosphorylates KHDRBS2 (Sus scrofa)
PTK6 phosphorylates KHDRBS2 (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2016-01-05)
Reviewed
Pires, IM  (2016-02-07)
Created
Orlic-Milacic, M  (2015-12-11)
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