PTK6 phosphorylates KHDRBS2

Stable Identifier
R-HSA-8849032
Type
Reaction
Species
Homo sapiens
Compartment
nucleoplasm
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PTK6 phosphorylates KHDRBS2
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Nuclear PTK6 (BRK) phosphorylates the RNA binding protein KHDRSB2 (SLM1) on an unknown tyrosine residue, thus inhibiting its interaction with RNA. KDRSB2 is a SAM68 (KHDRSB1) family member whose function has been poorly studied (Haegebarth et al. 2004).

Literature References
PubMed ID Title Journal Year
15471878 The nuclear tyrosine kinase BRK/Sik phosphorylates and inhibits the RNA-binding activities of the Sam68-like mammalian proteins SLM-1 and SLM-2

Richard, S, Bie, W, Derry, JJ, Haegebarth, A, Heap, D, Tyner, AL

J. Biol. Chem. 2004
Participants
Input
Output
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as an event of
Catalyst Activity

protein tyrosine kinase activity of p-Y342-PTK6 [nucleoplasm]

Physical Entity
p-Y342-PTK6 [nucleoplasm] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Orthologous Events
PTK6 phosphorylates KHDRBS2 (Danio rerio)
PTK6 phosphorylates KHDRBS2 (Mus musculus)
PTK6 phosphorylates KHDRBS2 (Rattus norvegicus)
PTK6 phosphorylates KHDRBS2 (Sus scrofa)
PTK6 phosphorylates KHDRBS2 (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2016-01-04)
Reviewed
Pires, IM  (2016-02-07)
Created
Orlic-Milacic, M  (2015-12-11)
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