Phosphorylation of DSIF by the P-TEFb(Cyclin T1:Cdk9) complex

Stable Identifier
R-HSA-170704
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Human immunodeficiency virus 1
Compartment
nucleoplasm
ReviewStatus
5/5
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Phosphorylation of DSIF by the P-TEFb(Cyclin T1:Cdk9) complex
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Phosphorylation of the Spt5 subunit of DSIF by P-TEFb(Cyclin T1:Cdk9) results in the conversion of DSIF to an elongation factor (Ivanov al. 2000).
Literature References
PubMed ID Title Journal Year
10757782 Domains in the SPT5 protein that modulate its transcriptional regulatory properties

Gaynor, RB, Kwak, YT, Ivanov, D, Guo, J

Mol Cell Biol 2000
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Catalyst Activity

RNA polymerase II CTD heptapeptide repeat kinase activity of Tat-containing early elongation complex with hyperphosphorylated Pol II CTD and phospho-NELF [nucleoplasm]

Physical Entity
Tat-containing early elongation complex with hyperphosphorylated Pol II CTD and phospho-NELF [nucleoplasm] (Homo sapiens)
Activity
RNA polymerase II CTD heptapeptide repeat kinase activity (GO:0008353)
Disease
Name Identifier Synonyms
Human immunodeficiency virus infectious disease DOID:526 HIV infection
Authored
Matthews, L  (2005-07-27)
Rice, AP  (2005-07-27)
Created
Matthews, L  (2006-01-13)
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