Phosphorylation of Cdc25A at Ser-123 by Chk2

Stable Identifier
R-HSA-69608
Type
Reaction
Species
Homo sapiens
Compartment
nucleoplasm
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Phosphorylation of Cdc25A at Ser-123 by Chk2
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Detection of DNA damage caused by ionizing radiation results in the phosphorylation of Cdc25A at Ser-123 by Chk2 (Mailand et al. 2001).

Literature References
PubMed ID Title Journal Year
11298456 The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis.

Lukas, J, Syljuåsen, RG, Mailand, N

Nature 2001
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Catalyst Activity

protein serine/threonine kinase activity of p-S,3T-CHEK2 [nucleoplasm]

Physical Entity
p-S,3T-CHEK2 [nucleoplasm] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
Phosphorylation of Cdc25A at Ser-123 by Chk2 (Danio rerio)
Phosphorylation of Cdc25A at Ser-123 by Chk2 (Dictyostelium discoideum)
Phosphorylation of Cdc25A at Ser-123 by Chk2 (Drosophila melanogaster)
Phosphorylation of Cdc25A at Ser-123 by Chk2 (Gallus gallus)
Phosphorylation of Cdc25A at Ser-123 by Chk2 (Mus musculus)
Phosphorylation of Cdc25A at Ser-123 by Chk2 (Rattus norvegicus)
Phosphorylation of Cdc25A at Ser-123 by Chk2 (Saccharomyces cerevisiae)
Phosphorylation of Cdc25A at Ser-123 by Chk2 (Schizosaccharomyces pombe)
Phosphorylation of Cdc25A at Ser-123 by Chk2 (Sus scrofa)
Phosphorylation of Cdc25A at Ser-123 by Chk2 (Xenopus tropicalis)
Created
Hoffmann, I  (2003-06-05)
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