AURKB phosphorylates TP53

Stable Identifier
R-HSA-6805126
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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AURKB (Aurora kinase B) phosphorylates TP53 (p53) at serine residue S269 and threonine residue T284, which inhibits TP53 transcriptional activity (Wu et al. 2011).

Literature References
PubMed ID Title Journal Year
20959462 Aurora B interacts with NIR-p53, leading to p53 phosphorylation in its DNA-binding domain and subsequent functional suppression

Wu, L, Ma, CA, Zhao, Y, Jain, A

J. Biol. Chem. 2011
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of AURKB:NOC2L:p-S15,S20-TP53 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
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