Reactome | CSNK1D,E phosphorylates CLOCK in p-S-CRY:p-S-PER:CSNK1D,E:p-S90,Ac-538-BMAL:p-2T,3S-CLOCK:target gene

CSNK1D,E phosphorylates CLOCK in p-S-CRY:p-S-PER:CSNK1D,E:p-S90,Ac-538-BMAL:p-2T,3S-CLOCK:target gene

Stable Identifier

R-HSA-9922273

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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CSNK1D,E phosphorylates CLOCK in p-S-CRY:p-S-PER:CSNK1D,E:p-S90,Ac-538-BMAL:p-2T,3S-CLOCK:target gene

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Cryptochrome (CRY) and Period (PER) proteins form complexes with the kinase CSNK1D (CK1delta) and/or CSNK1E (CK1epsilon) and bind the BMAL1:CLOCK heterodimer at promoters of target genes. The CRY:PER:kinase complex thereby brings CSNK1D and/or CSNK1E into proximity with CLOCK, resulting in the phosphorylation of CLOCK (inferred from mouse homologs).The residues phosphorylated by CSNK1D,E may be serine-38 and serine-42, which are located in the DNA-binding region of CLOCK and are observed to undergo cyclic phosphorylation that causes weakened transactivation and DNA-binding activity of BMAL1:CLOCK (inferred from mouse homologs in Yoshitane et al. 2009).

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