Phosphorylation of ChREBP at Thr(666) by PKA

Stable Identifier
R-HSA-163672
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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In its active (unphosphorylated) form, ChREBP (Carbohydrate Response Element Binding Protein) binds so-called ChRE (Carbohydrate Response Element) DNA sequence motifs found upstream of several genes involved in glucose utilization and lipid synthesis, activating transcription of these genes. Phosphorylation of ChREBP at threonine residue 666 by PKA (protein kinase A) blocks this binding activity, and thus has the effect of down-regulating expression of the target genes. ChREBP phosphorylation can be reversed by the action of protein phosphatase 2A (PP2A).

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
cAMP-dependent protein kinase activity of Protein Kinase A, catalytic subunits [nucleoplasm]
Physical Entity
Activity
Inferred From
Authored
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