SRC phosphorylates RUNX1

Stable Identifier
R-HSA-8937728
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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SRC phosphorylates RUNX1
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Based on studies in developing mouse megakaryocytes and T cells, SRC phosphorylates RUNX1 at seven tyrosine residues in the negative regulatory domain (Y254, Y258, Y260, Y376, Y379, Y380 and Y387). Endogenous human RUNX1 is tyrosine phosphorylated, and tyrosine residues in murine Runx1 that are phosphorylated by Src are conserved in human RUNX1. SRC-mediated phosphorylation interferes with binding of RUNX1 to GATA1, thus negatively regulating differentiation of hematopoietic progenitors. SRC-mediated phosphorylation promotes association of RUNX1 with the SWI/SNF complex (Huang et al. 2012).
Literature References
PubMed ID Title Journal Year
22759635 A Src family kinase-Shp2 axis controls RUNX1 activity in megakaryocyte and T-lymphocyte differentiation

Waldon, Z, Zhu, HH, Woo, AJ, Steen, H, Feng, GS, Schindler, Y, Cantor, AB, Huang, H, Moran, TB

Genes Dev. 2012
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Output
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as an event of
Catalyst Activity

protein tyrosine kinase activity of p-Y419-SRC:RUNX1 [nucleoplasm]

Physical Entity
p-Y419-SRC:RUNX1 [nucleoplasm] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Inferred From
Src phosphorylates Runx1 (Mus musculus)
Authored
Orlic-Milacic, M  (2016-09-14)
Reviewed
Chuang, LS  (2016-12-20)
Ito, Y  (2016-12-20)
Created
Orlic-Milacic, M  (2016-09-06)
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