Recognition of p27 by SCF(Skp2) and the subsequent ubiquitination of p27 is dependent upon Cyclin E/A:Cdk2-mediated phosphorylation of p27 at Thr 187 (Montagnoli et al., 1999). p21 is also phosphorylated at a specific site (Ser130) by Cyclin E/A:Cdk2, stimulating its ubiquitination. Unlike p27, however, p21 ubiquitination can take place in the absence of phosphorylation, although with less efficiency (Bornstein et al.,2003).
Ko, TK, Ganoth, D, Hershko, A, Bornstein, G, Tyers, M, Pagano, M, Larsen, B
Eytan, E, Draetta, GF, Hershko, A, Montagnoli, A, Pagano, M, Carrano, AC, Fiore, F
cyclin-dependent protein serine/threonine kinase activity of Cyclin A:Cdk2:p21/p27 complex [nucleoplasm]
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