Reactome | Cyclin A:Cdk2 mediated phosphorylation of p27/p21

Cyclin A:Cdk2 mediated phosphorylation of p27/p21

Stable Identifier

R-HSA-187916

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Cyclin A:Cdk2 mediated phosphorylation of p27/p21

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Recognition of p27 by SCF(Skp2) and the subsequent ubiquitination of p27 is dependent upon Cyclin E/A:Cdk2-mediated phosphorylation of p27 at Thr 187 (Montagnoli et al., 1999). p21 is also phosphorylated at a specific site (Ser130) by Cyclin E/A:Cdk2, stimulating its ubiquitination. Unlike p27, however, p21 ubiquitination can take place in the absence of phosphorylation, although with less efficiency (Bornstein et al.,2003).

Literature References

PubMed ID	Title	Journal	Year
11231585	The cell-cycle regulatory protein Cks1 is required for SCF(Skp2)-mediated ubiquitinylation of p27 Ganoth, D, Bornstein, G, Ko, TK, Larsen, B, Tyers, M, Pagano, M, Hershko, A	Nat Cell Biol	2001
10323868	Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation Montagnoli, A, Fiore, F, Eytan, E, Carrano, AC, Draetta, GF, Hershko, A, Pagano, M	Genes Dev	1999