MSK1 activates CREB

Stable Identifier
R-HSA-199935
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
MSK1 activates CREB
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
MSK1 is required for the mitogen-induced phosphorylation of the transcription factor, cAMP response element-binding protein (CREB).
Literature References
PubMed ID Title Journal Year
9687510 Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB

Deak, M, Clifton, AD, Lucocq, LM, Alessi, DR

EMBO J 1998
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein serine/threonine kinase activity of p-S212,S360,S376,T581-RPS6KA5 [nucleoplasm]

Physical Entity
p-S212,S360,S376,T581-RPS6KA5 [nucleoplasm] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
MSK1 activates CREB (Bos taurus)
MSK1 activates CREB (Caenorhabditis elegans)
MSK1 activates CREB (Canis familiaris)
MSK1 activates CREB (Danio rerio)
MSK1 activates CREB (Drosophila melanogaster)
MSK1 activates CREB (Gallus gallus)
MSK1 activates CREB (Mus musculus)
MSK1 activates CREB (Rattus norvegicus)
MSK1 activates CREB (Sus scrofa)
Authored
Nasi, S  (2006-10-10)
Annibali, D  (2006-10-10)
Reviewed
Greene, LA  (2007-11-08)
Created
Jassal, B  (2007-07-13)
Cite Us!