Phosphorylation of BRCA1-A complex at multiple sites by ATM

Stable Identifier
Reaction [transition]
Homo sapiens
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ATM phosphorylates BRCA1 at serine residues S1387, S1423, S1457, and S1524 (Cortez et al. 1999, Gatei et al. 2000). At least a fraction of these sites and some additional BRCA1 SQ/TQ sites can also be phosphorylated by ATR (Tibbetts et al. 2000). ATM also phosphorylates BARD1, the heterodimerization partner of BRCA1, at threonine residues T714 and T734 (Kim et al. 2006).

Literature References
PubMed ID Title Journal Year
16651405 DNA damage-induced BARD1 phosphorylation is critical for the inhibition of messenger RNA processing by BRCA1/BARD1 complex

Fonseca, D, Li, H, Cevher, M, Kleiman, FE, Lee, SB, Kim, HS, Parmelee, A

Cancer Res. 2006
11114888 Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress

Tibbetts, RS, Abraham, RT, Cortez, D, Livingston, D, Brumbaugh, KM, Elledge, SJ, Scully, R

Genes Dev. 2000
10866324 Role for ATM in DNA damage-induced phosphorylation of BRCA1

Weber, B, Scott, SP, Lavin, MF, Filippovitch, I, Khanna, KK, Soronika, N, Gatei, M

Cancer Res. 2000
10550055 Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks

Elledge, SJ, Wang, Y, Cortez, D, Qin, J

Science 1999
Catalyst Activity

protein serine/threonine kinase activity of DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:BRCA1-A complex [nucleoplasm]

Orthologous Events
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