CHEK2 phosphorylates BRCA1

Stable Identifier
R-HSA-5683801
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
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CHEK2 phosphorylates BRCA1
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Activated CHEK2 phosphorylates BRCA1 on serine residue S988 (Lee et al. 2000), but does not phosphorylate BARD1, the heterodimerization partner of BRCA1 (Kim et al. 2006).

Literature References
PubMed ID Title Journal Year
10724175 hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response

Lee, JS, Collins, KM, Brown, AL, Lee, CH, Chung, JH

Nature 2000
16651405 DNA damage-induced BARD1 phosphorylation is critical for the inhibition of messenger RNA processing by BRCA1/BARD1 complex

Kim, HS, Li, H, Cevher, M, Parmelee, A, Fonseca, D, Kleiman, FE, Lee, SB

Cancer Res. 2006
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of p-S,3T-CHEK2 [nucleoplasm]
Physical Entity
p-S,3T-CHEK2 [nucleoplasm]
Activity
protein serine/threonine kinase activity (0004674)
Orthologous Events
CHEK2 phosphorylates BRCA1 (Bos taurus)
CHEK2 phosphorylates BRCA1 (Canis familiaris)
CHEK2 phosphorylates BRCA1 (Danio rerio)
CHEK2 phosphorylates BRCA1 (Gallus gallus)
CHEK2 phosphorylates BRCA1 (Mus musculus)
CHEK2 phosphorylates BRCA1 (Rattus norvegicus)
CHEK2 phosphorylates BRCA1 (Sus scrofa)
CHEK2 phosphorylates BRCA1 (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2015-05-12)
Reviewed
Borowiec, JA  (2015-06-12)
Created
Orlic-Milacic, M  (2015-03-17)