CHEK2 phosphorylates BRCA1

Stable Identifier
R-HSA-5683801
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Activated CHEK2 phosphorylates BRCA1 on serine residue S988 (Lee et al. 2000), but does not phosphorylate BARD1, the heterodimerization partner of BRCA1 (Kim et al. 2006).

Literature References
PubMed ID Title Journal Year
10724175 hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response

Lee, JS, Collins, KM, Brown, AL, Lee, CH, Chung, JH

Nature 2000
16651405 DNA damage-induced BARD1 phosphorylation is critical for the inhibition of messenger RNA processing by BRCA1/BARD1 complex

Kim, HS, Li, H, Cevher, M, Parmelee, A, Fonseca, D, Kleiman, FE, Lee, SB

Cancer Res. 2006
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of p-S,3T-CHEK2 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created