Phosphorylation of Cdh1 by Cyclin B1:Cdc2

Stable Identifier
R-HSA-174251
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Phosphorylation of Cdh1 by Cyclin B1:Cdc2
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At the onset of mitosis, Cdh1 is phosphorylated by Cyclin B-Cdc2 resulting in a conformational change that prevents Cdh1 from activating the APC/C.
Literature References
PubMed ID Title Journal Year
11598127 Regulation of the anaphase-promoting complex by the dual specificity phosphatase human Cdc14a

Bembenek, J, Yu, H

J Biol Chem 2001
Participants
Input
Output
Participates
as an event of
Catalyst Activity

cyclin-dependent protein serine/threonine kinase activity of CCNB1:p-T161-CDK1 [nucleoplasm]

Physical Entity
CCNB1:p-T161-CDK1 [nucleoplasm] (Homo sapiens)
Activity
cyclin-dependent protein serine/threonine kinase activity (GO:0004693)
Orthologous Events
Phosphorylation of Cdh1 by Cyclin B1:Cdc2 (Bos taurus)
Phosphorylation of Cdh1 by Cyclin B1:Cdc2 (Canis familiaris)
Phosphorylation of Cdh1 by Cyclin B1:Cdc2 (Danio rerio)
Phosphorylation of Cdh1 by Cyclin B1:Cdc2 (Drosophila melanogaster)
Phosphorylation of Cdh1 by Cyclin B1:Cdc2 (Mus musculus)
Phosphorylation of Cdh1 by Cyclin B1:Cdc2 (Rattus norvegicus)
Phosphorylation of Cdh1 by Cyclin B1:Cdc2 (Sus scrofa)
Phosphorylation of Cdh1 by Cyclin B1:Cdc2 (Xenopus tropicalis)
Authored
Castro, A  (2006-01-26)
Lorca, T  (2006-01-26)
Reviewed
Peters, JM  (2006-03-28)
Created
Matthews, L  (2006-02-17)
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