Reactome | p-PKR dimer phosphorylates TP53 tetramer

p-PKR dimer phosphorylates TP53 tetramer

Stable Identifier

R-HSA-9836362

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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p-PKR dimer phosphorylates TP53 tetramer

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Activated protein kinase R (PKR, EIF2AK2) phosphorylates tumor antigen p53 (TP53) at S392, but it is unclear if subsequent p53 activation is due to this modification or to the SUMOylation of p53 by a PRKRA/PKR/UBE2I complex (Yeung et al, 1998; Cuddihy et al, 1999a; Cuddihy et al, 1999b; Rahman et al, 2009; Yoon et al, 2009; Bennett et al, 2012; Song et al, 2015).

Literature References

PubMed ID	Title	Journal	Year
19416861	PKR, a p53 target gene, plays a crucial role in the tumor-suppressor function of p53 Lim, DS, Bae, YS, Lee, ES, Yoon, CH	Proc Natl Acad Sci U S A	2009
22214662	The RAX/PACT-PKR stress response pathway promotes p53 sumoylation and activation, leading to G₁ arrest Hui, T, May, WS, Christian, J, Pan, Y, Bennett, RL	Cell Cycle	2012
10082513	Double-stranded-RNA-activated protein kinase PKR enhances transcriptional activation by tumor suppressor p53 Bell, JC, Li, S, Tam, NW, Wong, AH, Cuddihy, AR, Koromilas, AE, Taya, Y, Abraham, N	Mol Cell Biol	1999
9737981	Tumor suppressor p53 as a component of the tumor necrosis factor-induced, protein kinase PKR-mediated apoptotic pathway in human promonocytic U937 cells Yeung, MC, Lau, AS	J Biol Chem	1998
10348343	The double-stranded RNA activated protein kinase PKR physically associates with the tumor suppressor p53 protein and phosphorylates human p53 on serine 392 in vitro Li, S, Tam, NW, Wong, AH, Cuddihy, AR, Koromilas, AE	Oncogene	1999
19838063	PKR is not a universal target of tumor suppressor p53 in response to genotoxic stress Lem, C, Rahman, M, Koromilas, AE, Muaddi, H	Cell Cycle	2009
26446704	Activated PKR inhibits pancreatic β-cell proliferation through sumoylation-dependent stabilization of P53 Wan, X, Guo, J, Pan, Y, Xie, W, Wang, H, Gao, L, Song, Y	Mol Immunol	2015