p-PKR dimer phosphorylates TP53 tetramer

Stable Identifier
Reaction [transition]
Homo sapiens
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Activated protein kinase R (PKR, EIF2AK2) phosphorylates tumor antigen p53 (TP53) at S392, but it is unclear if subsequent p53 activation is due to this modification or to the SUMOylation of p53 by a PRKRA/PKR/UBE2I complex (Yeung et al, 1998; Cuddihy et al, 1999a; Cuddihy et al, 1999b; Rahman et al, 2009; Yoon et al, 2009; Bennett et al, 2012; Song et al, 2015).
Literature References
PubMed ID Title Journal Year
19416861 PKR, a p53 target gene, plays a crucial role in the tumor-suppressor function of p53

Lim, DS, Bae, YS, Lee, ES, Yoon, CH

Proc Natl Acad Sci U S A 2009
22214662 The RAX/PACT-PKR stress response pathway promotes p53 sumoylation and activation, leading to G₁ arrest

Hui, T, May, WS, Christian, J, Pan, Y, Bennett, RL

Cell Cycle 2012
10082513 Double-stranded-RNA-activated protein kinase PKR enhances transcriptional activation by tumor suppressor p53

Bell, JC, Li, S, Tam, NW, Wong, AH, Cuddihy, AR, Koromilas, AE, Taya, Y, Abraham, N

Mol Cell Biol 1999
9737981 Tumor suppressor p53 as a component of the tumor necrosis factor-induced, protein kinase PKR-mediated apoptotic pathway in human promonocytic U937 cells

Yeung, MC, Lau, AS

J Biol Chem 1998
10348343 The double-stranded RNA activated protein kinase PKR physically associates with the tumor suppressor p53 protein and phosphorylates human p53 on serine 392 in vitro

Li, S, Tam, NW, Wong, AH, Cuddihy, AR, Koromilas, AE

Oncogene 1999
19838063 PKR is not a universal target of tumor suppressor p53 in response to genotoxic stress

Lem, C, Rahman, M, Koromilas, AE, Muaddi, H

Cell Cycle 2009
26446704 Activated PKR inhibits pancreatic β-cell proliferation through sumoylation-dependent stabilization of P53

Wan, X, Guo, J, Pan, Y, Xie, W, Wang, H, Gao, L, Song, Y

Mol Immunol 2015
Catalyst Activity

protein kinase activity of p-EIF2AK2 dimer [nucleoplasm]

Orthologous Events
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