Phosphorylation of Chk1 by ATM upon DNA damage

Stable Identifier
R-GGA-217136
Type
Reaction [transition]
Species
Gallus gallus
Compartment
nucleoplasm
ReviewStatus
5/5
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Phosphorylation of Chk1 by ATM upon DNA damage
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Although ATM is dispensable for Chk1 phosphorylation, caffeine abrogated centrosome amplification in both ATM (ataxia telangiectasia, mutated)- and ATR (ATM and Rad3-related)-defective cells, indicates a complementary or redundant role for these DNA-damage-responsive kinases in Chk1 phosphorylation and the centrosomal responses to DNA damage.
Literature References
PubMed ID Title Journal Year
17468739 DNA damage induces Chk1-dependent centrosome amplification

Walker, M, Cuffe, L, Dodson, H, Gillespie, D, Merdes, A, Zachos, G, Morrison, CG, Bourke, E

EMBO Rep 2007
15311285 Centrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk1 kinase

Sylju?sen, RG, Lukas, J, Nigg, EA, Kramer, A, Lukas, C, Bartek, J, Wilkinson, CJ, Mailand, N

Nat Cell Biol 2004
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Output
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as an event of
Catalyst Activity

protein serine/threonine kinase activity of ATM [nucleoplasm]

Physical Entity
ATM [nucleoplasm] (Gallus gallus)
Activity
protein serine/threonine kinase activity (GO:0004674)
Authored
Saxena, A  (2008-01-04)
Reviewed
Borowiec, JA  (2009-04-24)
Created
Saxena, A  (2008-03-26)
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