Phosphorylation of FANCG at S7

Stable Identifier
R-GGA-265951
Type
Reaction [transition]
Species
Gallus gallus
Compartment
nucleoplasm
ReviewStatus
5/5
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Phosphorylation of FANCG at S7
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Chicken DT40 cells lacking FANCG (one of the proteins of the FA nuclear core complex) not only have decreased HR capacity for repairing enzymatically-induced, site-specific chromosomal DSBs but also elevated IR induced chromosomal aberrations in cells in late S and G2 phases. ATR (CHK1) catalyzes the phosphorylation of FANCG on serine 7. This reaction is essential for the direct FANCD2 BRCA2 interaction, as well as for the interactions of FANCG with BRCA2, XRCC3 and FANCD2. FANCG may have functions in parallel with BRCA2 or RAD51 paralogs in HR.
Literature References
PubMed ID Title Journal Year
12861027 Fanconi anemia FANCG protein in mitigating radiation- and enzyme-induced DNA double-strand breaks by homologous recombination in vertebrate cells

Matsushita, N, Harada, M, Takata, M, Buerstedde, JM, Arakawa, H, Thompson, LH, Tanimoto, M, Ishiai, M, Lamerdin, JE, Yamamoto, K

Mol Cell Biol 2003
18212739 FANCG promotes formation of a newly identified protein complex containing BRCA2, FANCD2 and XRCC3

Hussain, S, Hoatlin, ME, Takata, M, Mathew, CG, Kupfer, GM, Thompson, LH, Wilson, JB, Jones, NJ, Marriott, AS, Sung, P, Yamamoto, K

Oncogene 2008
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein serine/threonine kinase activity of ATR [nucleoplasm]

Physical Entity
ATR [nucleoplasm] (Gallus gallus)
Activity
protein serine/threonine kinase activity (GO:0004674)
Authored
Saxena, A  (2008-01-04)
Reviewed
Borowiec, JA  (2009-04-24)
Created
Saxena, A  (2008-04-21)
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