PTK6 phosphorylates KHDRBS1 (SAM68) on tyrosine residues Y435, Y440 and Y443, located within the nuclear localization signal (NLS) of KHDRBS1 (Lukong et al. 2005). PTK6-mediated phosphorylation inhibits the interaction of KHDRBS1 with RNA (Derry et al. 2000, Coyle et al. 2003).
Tyner, AL, Richard, S, Chen, T, Ye, X, Valderrama Carvajal, H, Cochrane, AW, Derry, JJ, Vasioukhin, V
Richard, S, Lukong, KE, Larocque, D, Tyner, AL
Coyle, JH, Eisner-Smerage, L, Guzik, BW, Bor, YC, Rekosh, D, Jin, L, Hammarskjold, ML, Taylor, SJ
protein tyrosine kinase activity of p-Y342-PTK6:KHDRBS1 [nucleoplasm]
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