RPS6KA1/2/3 phosphorylates CEBPB on S321

Stable Identifier
R-HSA-3857328
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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RPS6KA1/2/3 phosphorylates CEBPB on S321
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Phosphorylation of CEBPB (C/EBP-beta) serine residue S321 by ERK1/2-activated RSK1, RSK2 or RSK3, downstream of activated RAS, is necessary for the relief of CEBPB autoinhibiton (Lee et al. 2010). Phosphorylation on other sites may also be involved in CEBPB activation.
Literature References
PubMed ID Title Journal Year
20351173 RSK-mediated phosphorylation in the C/EBP{beta} leucine zipper regulates DNA binding, dimerization, and growth arrest activity

Lee, S, Shuman, JD, Guszczynski, T, Sakchaisri, K, Sebastian, T, Copeland, TD, Miller, M, Cohen, MS, Taunton, J, Smart, RC, Xiao, Z, Yu, LR, Veenstra, TD, Johnson, PF

Mol. Cell. Biol. 2010
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Catalyst Activity

protein serine/threonine kinase activity of Phospho-Ribosomal protein S6 kinase [nucleoplasm]

Physical Entity
Phospho-Ribosomal protein S6 kinase [nucleoplasm] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Inferred From
RPS6KA1/2/3 phosphorylates Cebpb on S273 (Homo sapiens)
Authored
Orlic-Milacic, M  (2013-07-15)
Reviewed
Samarajiwa, S  (2013-09-03)
Created
Orlic-Milacic, M  (2013-07-09)
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