MAPKAPK5 phosphorylates TP53

Stable Identifier
R-HSA-3239014
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Activated MAPKAPK5 (PRAK) phosphorylates TP53 (p53) on serine residue S37, thereby activating it. MAPKAPK5-mediated phosphorylation of TP53 promotes growth arrest and senescence induced by oncogenic RAS, but is not needed for TP53-dependent growth arrest in response to DNA damage (Sun et al. 2007).

Literature References
PubMed ID Title Journal Year
17254968 PRAK is essential for ras-induced senescence and tumor suppression

Sun, P, Yoshizuka, N, New, L, Moser, BA, Li, Y, Liao, R, Xie, C, Chen, J, Deng, Q, Yamout, M, Dong, MQ, Frangou, CG, Yates, JR, Wright, PE, Han, J

Cell 2007
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of phospho-p38 MAPK:p-T-182-MAPKAPK5 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created