PTK6 phosphorylates SFPQ

Stable Identifier
R-HSA-8849463
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
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PTK6 phosphorylates SFPQ
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PTK6 (BRK) binds a large RNA processing nuclear complex that contains SFPQ (PSF) and phosphorylates SFPQ on C-terminal tyrosine residues. PTK6 also phosphorylates at least two additional SFPQ-associated unidentified proteins.

PTK6-mediated phosphorylation disrupts SFPQ binding to RNA and may promote the relocalization of SFPQ to the cytosol and cell cycle arrest (Lukong et al. 2009).

Literature References
PubMed ID Title Journal Year
19439179 BRK phosphorylates PSF promoting its cytoplasmic localization and cell cycle arrest

Lukong, KE, Huot, ME, Richard, S

Cell. Signal. 2009
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of p-Y342-PTK6 [nucleoplasm]
Physical Entity
p-Y342-PTK6 [nucleoplasm]
Activity
protein tyrosine kinase activity (0004713)
Orthologous Events
PTK6 phosphorylates SFPQ (Bos taurus)
PTK6 phosphorylates SFPQ (Caenorhabditis elegans)
PTK6 phosphorylates SFPQ (Danio rerio)
PTK6 phosphorylates SFPQ (Mus musculus)
PTK6 phosphorylates SFPQ (Sus scrofa)
PTK6 phosphorylates SFPQ (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2016-01-04)
Reviewed
Pires, IM  (2016-02-07)
Created
Orlic-Milacic, M  (2015-12-15)