RPS6KA1/2/3 phosphorylates Cebpb on S273

Stable Identifier
R-NUL-3876071
Type
Reaction [transition]
Species
Homo sapiens
Compartment
General
SVG |   | PPTX  | SBGN
RPS6KA1/2/3 phosphorylates Cebpb on S273

Phosphorylation of rat Cebpb (C/EBP-beta) serine residue S273 by ERK1/2-activated human RSK1, mouse RSK2 or human RSK3, downstream of activated RAS, is necessary for the relief of Cebpb autoinhibiton (Lee et al. 2010). Phosphorylation on other sites may also be involved in Cebpb activation.

Literature References
PubMed ID Title Journal Year
20351173 RSK-mediated phosphorylation in the C/EBP{beta} leucine zipper regulates DNA binding, dimerization, and growth arrest activity

Lee, S, Shuman, JD, Guszczynski, T, Sakchaisri, K, Sebastian, T, Copeland, TD, Miller, M, Cohen, MS, Taunton, J, Smart, RC, Xiao, Z, Yu, LR, Veenstra, TD, Johnson, PF

Mol. Cell. Biol. 2010
Participants
Catalyst Activity

protein serine/threonine kinase activity of Phospho-Ribosomal protein S6 kinase [nucleoplasm]

Orthologous Events
Authored
Reviewed
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