Reactome | HIPK2 phosphorylates TP53

HIPK2 phosphorylates TP53

Stable Identifier

R-HSA-6799409

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Activity through Phosphorylation (Homo sapiens)
        
        HIPK2 phosphorylates TP53 (Homo sapiens)

General

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HIPK2, activated by autophosphorylation in response to DNA damage, phosphorylates TP53 (p53) at serine residue S46 (D'Orazi et al. 2002, Hofmann et al. 2002). A TP53 transcriptional target TP53INP1 facilitates TP53 phosphorylation at S46 in response to double strand breaks and, together with HIPK2, promotes the transcription of TP53 apoptotic gene targets (Okamura et al. 2001, Tomasini et al. 2003).

Literature References

PubMed ID	Title	Journal	Year
12851404	TP53INP1s and homeodomain-interacting protein kinase-2 (HIPK2) are partners in regulating p53 activity Tomasini, R, Samir, AA, Carrier, A, Isnardon, D, Cecchinelli, B, Soddu, S, Malissen, B, Dagorn, JC, Iovanna, JL, Dusetti, NJ	J. Biol. Chem.	2003
11780126	Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis D'Orazi, G, Cecchinelli, B, Bruno, T, Manni, I, Higashimoto, Y, Saito, S, Gostissa, M, Coen, S, Marchetti, A, Del Sal, G, Piaggio, G, Fanciulli, M, Appella, E, Soddu, S	Nat. Cell Biol.	2002
11511362	p53DINP1, a p53-inducible gene, regulates p53-dependent apoptosis Okamura, S, Arakawa, H, Tanaka, T, Nakanishi, H, Ng, CC, Taya, Y, Monden, M, Nakamura, Y	Mol. Cell	2001
11740489	Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2 Hofmann, TG, Möller, A, Sirma, H, Zentgraf, H, Taya, Y, Dröge, W, Will, H, Schmitz, ML	Nat. Cell Biol.	2002