NPM1-ALK- and JNK-dependent JUN phosphorylation

Stable Identifier
R-HSA-9851096
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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NPM1-ALK- and JNK-dependent JUN phosphorylation
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JUN is phosphorylated downstream of activated JNK in NPM1-ALK cells in a manner that depends on JNK and ALK kinasae activity (Leventaki et al, 2007). The JNK-JUN signaling axis contributes to the proliferatiion of ALCL cells by altering the expression of key cell-cycle factors such as CCND1 (cyclin D) and CDKN1A (p21) (Leventaki et al, 2007; Cui et al, 2009; reviewed in Shaulian et al, 2002).
Literature References
PubMed ID Title Journal Year
17416736 NPM-ALK oncogenic kinase promotes cell-cycle progression through activation of JNK/cJun signaling in anaplastic large-cell lymphoma

Drakos, E, Rassidakis, GZ, Elenitoba-Johnson, KS, Lim, MS, Claret, FX, Medeiros, LJ, Leventaki, V

Blood 2007
11988758 AP-1 as a regulator of cell life and death

Shaulian, E, Karin, M

Nat. Cell Biol. 2002
19286999 NPM-ALK inhibits the p53 tumor suppressor pathway in an MDM2 and JNK-dependent manner

McDuff, FK, Turner, SD, Kerby, A, Ye, H, Cui, YX

Blood 2009
Participants
Input
Output
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as an event of
This event is regulated
Positively by
Regulator
p-T,Y MAPK8,9 [nucleoplasm] (Homo sapiens)
Disease
Name Identifier Synonyms
anaplastic large cell lymphoma DOID:0050744
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Authored
Rothfels, K  (2023-10-14)
Reviewed
Turner, S  (2023-11-08)
Created
Rothfels, K  (2023-10-12)
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