Phosphorylation of Cyclin E:CDK2 complexes by WEE1

Stable Identifier
R-HSA-69195
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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WEE1 phosphorylates CDK2, inhibiting entry into S-phase (Watanabe et al., 1995; Wu et al., 2001). WEE1-mediated phosphorylation of CDK2 is enhanced in the presence of CABLES1, which can form a complex with CDK2 bound to cyclin E (CCNE) or cyclin A (CCNA) (Wu et al. 2001).

Literature References
PubMed ID Title Journal Year
11585773 Cables enhances cdk2 tyrosine 15 phosphorylation by Wee1, inhibits cell growth, and is lost in many human colon and squamous cancers

Wu, CL, Kirley, SD, Xiao, H, Chuang, Y, Chung, DC, Zukerberg, LR

Cancer Res 2001
7743995 Regulation of the human WEE1Hu CDK tyrosine 15-kinase during the cell cycle

Watanabe, N, Broome, M, Hunter, T

EMBO J 1995
Participants
Participant Of
Event Information
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of WEE1 [nucleoplasm]
Physical Entity
Activity
This event is regulated
Positively by
Orthologous Events