Phosphorylation of Cyclin E:CDK2 complexes by WEE1

Stable Identifier
Reaction [transition]
Homo sapiens
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WEE1 phosphorylates CDK2, inhibiting entry into S-phase (Watanabe et al., 1995; Wu et al., 2001). WEE1-mediated phosphorylation of CDK2 is enhanced in the presence of CABLES1, which can form a complex with CDK2 bound to cyclin E (CCNE) or cyclin A (CCNA) (Wu et al. 2001).
Literature References
PubMed ID Title Journal Year
7743995 Regulation of the human WEE1Hu CDK tyrosine 15-kinase during the cell cycle

Broome, M, Hunter, T, Watanabe, N

EMBO J 1995
11585773 Cables enhances cdk2 tyrosine 15 phosphorylation by Wee1, inhibits cell growth, and is lost in many human colon and squamous cancers

Chung, DC, Zukerberg, LR, Xiao, H, Chuang, Y, Wu, CL, Kirley, SD

Cancer Res 2001
Event Information
Catalyst Activity

protein tyrosine kinase activity of WEE1 [nucleoplasm]

This event is regulated
Positively by
Orthologous Events
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