CK2:FACT phosphorylates TP53

Stable Identifier
R-HSA-6805059
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Casein kinase II (CK2), associated with the FACT2 complex, phosphorylates TP53 (p53) at serine residue S392, enhancing transcriptional activity of TP53 in response to UV irradiation (Keller et al. 2001, Keller and Lu 2002).

Literature References
PubMed ID Title Journal Year
11239457 A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1

Keller, DM, Zeng, X, Wang, Y, Zhang, QH, Kapoor, M, Shu, H, Goodman, R, Lozano, G, Zhao, Y, Lu, H

Mol. Cell 2001
12393879 p53 serine 392 phosphorylation increases after UV through induction of the assembly of the CK2.hSPT16.SSRP1 complex

Keller, DM, Lu, H

J. Biol. Chem. 2002
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of CK2:FACT [nucleoplasm]
Physical Entity
Activity
Orthologous Events
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Created