Reactome | CDK1 phosphorylates condensin II subunit NCAPD3

CDK1 phosphorylates condensin II subunit NCAPD3

Stable Identifier

R-HSA-2294600

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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CDK1 phosphorylates condensin II subunit NCAPD3

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Phosphorylation of the threonine residue T1415 of condensin II subunit NCAPD3 is required for chromosome condensation in prophase. In vivo, phosphorylation of NCAPD3 threonine residue T1415 is blocked when cells are treated with CDK1 inhibitors. In addition, it was shown that CDK1 in complex with cyclin B1 (CDK1:CCNB1) phosphorylates NCAPD3 at T1415 in vitro (Abe et al. 2011).

Literature References

PubMed ID	Title	Journal	Year
21498573	The initial phase of chromosome condensation requires Cdk1-mediated phosphorylation of the CAP-D3 subunit of condensin II Abe, S, Nagasaka, K, Hirayama, Y, Kozuka-Hata, H, Oyama, M, Aoyagi, Y, Obuse, C, Hirota, T	Genes Dev.	2011