CDK1 phosphorylates condensin II subunit NCAPD3

Stable Identifier
R-HSA-2294600
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Phosphorylation of the threonine residue T1415 of condensin II subunit NCAPD3 is required for chromosome condensation in prophase. In vivo, phosphorylation of NCAPD3 threonine residue T1415 is blocked when cells are treated with CDK1 inhibitors. In addition, it was shown that CDK1 in complex with cyclin B1 (CDK1:CCNB1) phosphorylates NCAPD3 at T1415 in vitro (Abe et al. 2011).

Literature References
PubMed ID Title Journal Year
21498573 The initial phase of chromosome condensation requires Cdk1-mediated phosphorylation of the CAP-D3 subunit of condensin II

Abe, S, Nagasaka, K, Hirayama, Y, Kozuka-Hata, H, Oyama, M, Aoyagi, Y, Obuse, C, Hirota, T

Genes Dev. 2011
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
cyclin-dependent protein serine/threonine kinase activity of CCNB1:p-T161-CDK1 [nucleoplasm]
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Activity
Orthologous Events
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Created