Reactome | Mcm2-7 is phosphorylated by DDK

Mcm2-7 is phosphorylated by DDK

Stable Identifier

R-HSA-68954

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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At the beginning of this reaction, 1 molecule of 'Mcm2-7 complex', and 1 molecule of 'ATP' are present. At the end of this reaction, 1 molecule of 'phosphorylated Mcm2-7 complex', and 1 molecule of 'ADP' are present.

This reaction takes place in the 'nucleus' and is mediated by the 'kinase activity' of 'DDK'.

Literature References

PubMed ID	Title	Journal	Year
10846177	Human Cdc7-related kinase complex. In vitro phosphorylation of MCM by concerted actions of Cdks and Cdc7 and that of a critical threonine residue of Cdc7 by Cdks. Ishimi, Y, Arai, K, Tamai, K, Matsui, E, You, Z, Masai, H	J Biol Chem	2000