Phosphorylation of NEFL by the P-TEFb(Cyclin T1:Cdk9) complex

Stable Identifier
R-HSA-170706
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Human immunodeficiency virus 1
Compartment
nucleoplasm
ReviewStatus
5/5
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Phosphorylation of NEFL by the P-TEFb(Cyclin T1:Cdk9) complex
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Phosphorylation of the RD subunit of NEFL by P-TEFb(Cyclin T1:Cdk9) results in the dissociation of NEFL from TAR as well as the conversion of NEFL to an elongation factor (Fujinaga et al., 2004)
Literature References
PubMed ID Title Journal Year
14701750 Dynamics of human immunodeficiency virus transcription: P-TEFb phosphorylates RD and dissociates negative effectors from the transactivation response element

Fujinaga, K, Irwin, D, Huang, Y, Taube, R, Kurosu, T, Peterlin, BM

Mol Cell Biol 2004
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Output
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Catalyst Activity

RNA polymerase II CTD heptapeptide repeat kinase activity of Tat-containing early elongation complex with hyperphosphorylated Pol II CTD [nucleoplasm]

Physical Entity
Tat-containing early elongation complex with hyperphosphorylated Pol II CTD [nucleoplasm] (Homo sapiens)
Activity
RNA polymerase II CTD heptapeptide repeat kinase activity (GO:0008353)
Disease
Name Identifier Synonyms
Human immunodeficiency virus infectious disease DOID:526 HIV infection
Cross References
Mondo
Authored
Matthews, L  (2005-07-27)
Rice, AP  (2005-07-27)
Created
Matthews, L  (2006-01-13)
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