Phosphorylation of NEFL by the P-TEFb(Cyclin T1:Cdk9) complex

Stable Identifier
R-HSA-170706
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Human immunodeficiency virus 1
Compartment
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Phosphorylation of the RD subunit of NEFL by P-TEFb(Cyclin T1:Cdk9) results in the dissociation of NEFL from TAR as well as the conversion of NEFL to an elongation factor (Fujinaga et al., 2004)

Literature References
PubMed ID Title Journal Year
14701750 Dynamics of human immunodeficiency virus transcription: P-TEFb phosphorylates RD and dissociates negative effectors from the transactivation response element

Fujinaga, K, Irwin, D, Huang, Y, Taube, R, Kurosu, T, Peterlin, BM

Mol Cell Biol 2004
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
RNA polymerase II CTD heptapeptide repeat kinase activity of Tat-containing early elongation complex with hyperphosphorylated Pol II CTD [nucleoplasm]
Physical Entity
Activity
Disease
Name Identifier Synonyms
Human immunodeficiency virus infectious disease 526 HIV infection
Authored
Created
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