AKT can phosphorylate NR4A1 (NUR77)

Stable Identifier
R-HSA-199863
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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AKT can phosphorylate NR4A1 (NUR77)
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AKT inhibits DNA binding of NUR77 and inhibits its pro-apoptotic function (PMID 11438550). However, the relevance of AKT for NUR77 phosphorylation has recently been questioned: according to recent work, NUR77 is phosphorylated by RSK (and MSK) rather than by AKT (PMID 16223362).
Literature References
PubMed ID Title Journal Year
11274386 Akt phosphorylates and regulates the orphan nuclear receptor Nur77

Bullrich, F, Pekarsky, Y, Bichi, R, Koval, A, Letofsky, J, Hallas, C, Croce, CM, Palamarchuk, A, Hirata, Y

Proc Natl Acad Sci U S A 2001
Participants
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Output
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as an event of
Event Information
Go Biological Process
phosphatidylinositol 3-kinase/protein kinase B signal transduction (0043491)
Catalyst Activity

protein serine/threonine kinase activity of p-T,p-S-AKT [nucleoplasm]

Physical Entity
p-T,p-S-AKT [nucleoplasm] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
AKT can phosphorylate NR4A1 (NUR77) (Caenorhabditis elegans)
AKT can phosphorylate NR4A1 (NUR77) (Danio rerio)
AKT can phosphorylate NR4A1 (NUR77) (Drosophila melanogaster)
AKT can phosphorylate NR4A1 (NUR77) (Gallus gallus)
AKT can phosphorylate NR4A1 (NUR77) (Mus musculus)
AKT can phosphorylate NR4A1 (NUR77) (Rattus norvegicus)
Authored
Nasi, S  (2006-10-10)
Annibali, D  (2006-10-10)
Reviewed
Greene, LA  (2007-11-08)
Created
Jassal, B  (2007-07-12)
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