Reactome | AKT phosphorylates FOXO3 downstream of ESR1 and EGFR

AKT phosphorylates FOXO3 downstream of ESR1 and EGFR

Stable Identifier

R-HSA-9624526

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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AKT phosphorylates FOXO3 downstream of ESR1 and EGFR

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AKT phosphorylation of the pro-apoptotic Forkhead transcription factor FOXO3 and other Foxo family members occurs downstream of E2 stimulation (Richards et al, 2002; reviewed in Levin, 2005). AKT-mediated phosphorylation promotes nuclear export, resulting in a decrease in expression of apoptosis-promoting FOXO3-target genes (Brunet et al, 1999; reviewed in Burgering, 2008).

Literature References

PubMed ID	Title	Journal	Year
10102273	Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor Hu, LS, Bonni, A, Brunet, A, Blenis, J, Zigmond, MJ, Anderson, MJ, Lin, MZ, Greenberg, ME, Juo, P, Arden, KC	Cell	1999
18391968	A brief introduction to FOXOlogy Burgering, BM	Oncogene	2008
11875118	Expression of FKHR, FKHRL1, and AFX genes in the rodent ovary: evidence for regulation by IGF-I, estrogen, and the gonadotropins Lo, YH, Falender, AE, Richards, JS, Sharma, SC	Mol. Endocrinol.	2002
15705661	Integration of the extranuclear and nuclear actions of estrogen Levin, ER	Mol. Endocrinol.	2005