Activated JNK phosphorylates c-JUN

Stable Identifier
R-HSA-9673789
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Activated JNK phosphorylates c-JUN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
JNK (c-Jun N-terminal Kinase) phosphorylates several transcription factors including c-Jun after translocation to the nucleus.
Literature References
PubMed ID Title Journal Year
18793328 c-Jun expression, activation and function in neural cell death, inflammation and repair

Raivich, G

J Neurochem 2008
10871633 c-Jun inhibits transforming growth factor beta-mediated transcription by repressing Smad3 transcriptional activity

Dennler, S, Prunier, C, Ferrand, N, Gauthier, JM, Atfi, A

J Biol Chem 2000
Participants
Input
Output
Participates
as an event of
Catalyst Activity

JUN kinase activity of p-T,Y-MAPK8 [nucleoplasm]

Physical Entity
p-T,Y-MAPK8 [nucleoplasm] (Homo sapiens)
Activity
JUN kinase activity (GO:0004705)
Authored
Jassal, B  (2020-01-07)
Murillo, JI  (2020-01-07)
Reviewed
Gregory, DJ  (2020-02-04)
Created
Murillo, JI  (2020-01-09)
Cite Us!