Mapk1,(Mapk3) phosphorylate Npas4

Stable Identifier
R-MMU-9769840
Type
Reaction [transition]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Mapk1,(Mapk3) phosphorylate Npas4
Activation of Mapk1/Mapk3 upon Ngf treatment of rat pheochromocytoma cell line PC12 results in Npas4 phosphorylation and increased Npas4 transcriptional activity (Ooe et al. 2009). In mouse medium spiny neurons expressing dopamine D1 receptor (D1R), dopamine activates Mapk1 and Mapk3 via PKA and Rap1 signaling, leading to phosphorylation of nuclear Npas4. In vitro, it was shown that recombinant human MAPK1 phosphorylates mouse Npas4 on six conserved residues: T423, T427, S577, S580, T611, and S615. The same residues are phosphorylated in dopamine-treated MSNs expressing D1R and recombinant Npas4. Mapk1/3-mediated phosphorylation of Npas4 promotes its binding to Crebbp (Cbp), which, through an unknown mechanism, increases Npas4-mediated transcription of target genes, such as Bdnf (Funahashi et al. 2019).
Literature References
PubMed ID Title Journal Year
31801086 Phosphorylation of Npas4 by MAPK Regulates Reward-Related Gene Expression and Behaviors

Suzuki, K, Kuroda, K, Ahammad, RU, Nagai, T, Kaibuchi, K, Xu, Y, Shan, W, Takano, T, Kozawa, S, Wu, M, Amano, M, Ariza, A, Funahashi, Y, Yura, Y, Yamada, K, Emi, R

Cell Rep 2019
Participants
Input
Output
Catalyst Activity

protein serine/threonine kinase activity of Phospho-Mapk1,(Mapk3) [nucleoplasm]

Physical Entity
Phospho-Mapk1,(Mapk3) [nucleoplasm] (Mus musculus)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
MAPK1,(MAPK3) phosphorylates NPAS4 (Homo sapiens)
Authored
Orlic-Milacic, M  (2022-04-08)
Reviewed
Lin, Y  (2022-07-29)
Created
Orlic-Milacic, M  (2022-03-22)
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