Phosphorylation of Wee1 kinase by Chk1

Stable Identifier
R-SPO-75040
Type
Reaction [transition]
Species
Schizosaccharomyces pombe
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Phosphorylation of Wee1 kinase by Chk1
At the beginning of this reaction, 1 molecule of 'ATP', and 1 molecule of 'Wee1 POMBE' are present. At the end of this reaction, 1 molecule of 'phospho-Wee1 Pombe', and 1 molecule of 'ADP' are present.

This reaction takes place in the 'nucleoplasm' and is mediated by the 'kinase activity' of 'CHK1 (POMBE)'.
Literature References
PubMed ID Title Journal Year
9034337 Chk1 is a wee1 kinase in the G2 DNA damage checkpoint inhibiting cdc2 by Y15 phosphorylation.

Raleigh, JM, O'Connell, MJ, Nurse, P, Verkade, HM

EMBO J 1997
Participants
Input
Output
Catalyst Activity

protein serine/threonine kinase activity of CHK1 (POMBE) [nucleoplasm]

Physical Entity
CHK1 (POMBE) [nucleoplasm] (Schizosaccharomyces pombe)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
Phosphorylation of Wee1 kinase by Chk1 (Homo sapiens)
Created
Matthews, L  (2003-08-08)
Cite Us!