PRKAA2 phosphorylates nuclear NFE2L2

Stable Identifier
R-HSA-9796067
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
3/5
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PRKAA2 phosphorylates nuclear NFE2L2
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PRKAA2 phosphorylates NFE2L2 at the Ser558 residue (Ser550 in mouse) which is located in the canonical nuclear export signal leading to inhibition of NFE2L2 nuclear transport and enhanced nuclear retention. (Joo et al, 2016))
Literature References
PubMed ID Title Journal Year
27161318 AMPK Facilitates Nuclear Accumulation of Nrf2 by Phosphorylating at Serine 550

Lee, KY, Koo, JH, Kim, WD, Kim, JH, Kim, SG, Joo, MS

Mol Cell Biol 2016
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as an event of
Catalyst Activity

protein serine/threonine kinase activity of PRKAA2 [nucleoplasm]

Physical Entity
PRKAA2 [nucleoplasm] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
PRKAA2 phosphorylates nuclear NFE2L2 (Bos taurus)
PRKAA2 phosphorylates nuclear NFE2L2 (Caenorhabditis elegans)
PRKAA2 phosphorylates nuclear NFE2L2 (Canis familiaris)
PRKAA2 phosphorylates nuclear NFE2L2 (Drosophila melanogaster)
PRKAA2 phosphorylates nuclear NFE2L2 (Gallus gallus)
PRKAA2 phosphorylates nuclear NFE2L2 (Mus musculus)
PRKAA2 phosphorylates nuclear NFE2L2 (Rattus norvegicus)
PRKAA2 phosphorylates nuclear NFE2L2 (Sus scrofa)
Authored
Tiwari, K  (2023-08-08)
Created
Tiwari, K  (2022-08-04)
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