p-S MAPK6 phosphorylates NCOA3

Stable Identifier
Reaction [transition]
Homo sapiens
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MAPK6 is proposed to phosphorylate NCOA3 at serine 857. This phosphorylation is required for NCOA3 to interact with the transcription factor ETV4 (also known as PEA3). Together, ETV4 and NCOA3 bind to the promoters and regulate the expression of metalloprotease genes such as MMP2 and MMP10 and in this way contribute to cell motility and invasiveness in lung cancer (Long et al, 2012; Qin et al, 2008; Yan et al, 2008; Li et al, 2008; reviewed in Kostenko et al, 2012).
Literature References
PubMed ID Title Journal Year
22800433 Tumour promoting and suppressing roles of the atypical MAP kinase signalling pathway ERK3/4-MK5

Dumitriu, G, Kostenko, S, Moens, U

J Mol Signal 2012
18593949 Steroid receptor coactivator-3/AIB1 promotes cell migration and invasiveness through focal adhesion turnover and matrix metalloproteinase expression

Erdem, H, Tsai, SY, Yan, J, Li, R, Tsai, MJ, Ittmann, M, Ayala, G, Cai, Y, Yu-Lee, LY

Cancer Res. 2008
22505454 ERK3 signals through SRC-3 coactivator to promote human lung cancer cell invasion

O'Malley, BW, Foulds, CE, Tsai, SY, Liu, J, Long, W, Tsai, MJ, Wistuba, II, Lonard, DM, Ding, C, Qin, J, Qin, J, Solis, LM

J. Clin. Invest. 2012
18162290 Proto-oncogene ACTR/AIB1 promotes cancer cell invasion by up-regulating specific matrix metalloproteinase expression

Louie, MC, Zou, JX, Li, LB, Chen, HW

Cancer Lett. 2008
18644862 The AIB1 oncogene promotes breast cancer metastasis by activation of PEA3-mediated matrix metalloproteinase 2 (MMP2) and MMP9 expression

O'Malley, BW, Redmond, A, Yuan, Y, Chen, H, Qin, L, Xu, J, Young, L, Liao, L

Mol. Cell. Biol. 2008
Catalyst Activity

protein serine/threonine kinase activity of p-S189 MAPK6 [nucleoplasm]

Orthologous Events
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