Reactome | Phosphorylation of MEF2 proteins by p38

Phosphorylation of MEF2 proteins by p38

Stable Identifier

R-HSA-448955

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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The family of transcription factors myocyte enhancer factor-2 (MEF2) regulate myogenesis through combinatorial interactions with other transcription factors to the MEF2 site found in the promoter regions of numerous muscle specific genes. There are four members of the MEF2 family, MEF2A to D.
p38 MAPK plays a role in the regulation of the MEF2 family members and this is mediated by the phosphorylation of two or three (Thr312 and 319 in MEF2A and Thr 293, 300 and ser387 in MEF2C) amino acids in the C-terminal activation domain of MEF2 factors. MEF2A and MEF2C are preferred substrates for p38 compared with MEF2B and MEF2D. The phosphorylation of MEF2 members results in their increased transcriptional activity.

Literature References

PubMed ID	Title	Journal	Year
10805738	p38 and extracellular signal-regulated kinases regulate the myogenic program at multiple steps Wang, JY, Bhakta, KS, Tamura, K, Wu, Z, Feramisco, JR, Karin, M, Puri, PL, Woodring, PJ, Wen, F	Mol Cell Biol	2000
9988769	p38 mitogen-activated protein kinase pathway promotes skeletal muscle differentiation. Participation of the Mef2c transcription factor Gredinger, E, Zetser, A, Bengal, E	J Biol Chem	1999
9069290	Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation Ulevitch, RJ, Kravchenko, VV, Li, Z, Jiang, Y, Han, J	Nature	1997
10330143	Targeting of p38 mitogen-activated protein kinases to MEF2 transcription factors Sharrocks, AD, Yang, SH, Galanis, A	Mol Cell Biol	1999
9858528	Regulation of the MEF2 family of transcription factors by p38 Kato, Y, di Padova, F, Zhao, M, Ulevitch, RJ, Kravchenko, VV, Olson, EN, Han, J, Gram, H, New, L	Mol Cell Biol	1999