Phosphorylation of MEF2 proteins by p38

Stable Identifier
R-HSA-448955
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The family of transcription factors myocyte enhancer factor-2 (MEF2) regulate myogenesis through combinatorial interactions with other transcription factors to the MEF2 site found in the promoter regions of numerous muscle specific genes. There are four members of the MEF2 family, MEF2A to D.
p38 MAPK plays a role in the regulation of the MEF2 family members and this is mediated by the phosphorylation of two or three (Thr312 and 319 in MEF2A and Thr 293, 300 and ser387 in MEF2C) amino acids in the C-terminal activation domain of MEF2 factors. MEF2A and MEF2C are preferred substrates for p38 compared with MEF2B and MEF2D. The phosphorylation of MEF2 members results in their increased transcriptional activity.

Literature References
PubMed ID Title Journal Year
9988769 p38 mitogen-activated protein kinase pathway promotes skeletal muscle differentiation. Participation of the Mef2c transcription factor

Zetser, A, Gredinger, E, Bengal, E

J Biol Chem 1999
10805738 p38 and extracellular signal-regulated kinases regulate the myogenic program at multiple steps

Wu, Z, Woodring, PJ, Bhakta, KS, Tamura, K, Wen, F, Feramisco, JR, Karin, M, Wang, JY, Puri, PL

Mol Cell Biol 2000
9069290 Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation

Han, J, Jiang, Y, Li, Z, Kravchenko, VV, Ulevitch, RJ

Nature 1997
10330143 Targeting of p38 mitogen-activated protein kinases to MEF2 transcription factors

Yang, SH, Galanis, A, Sharrocks, AD

Mol Cell Biol 1999
9858528 Regulation of the MEF2 family of transcription factors by p38

Zhao, M, New, L, Kravchenko, VV, Kato, Y, Gram, H, di Padova, F, Olson, EN, Ulevitch, RJ, Han, J

Mol Cell Biol 1999
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of phospho-p38 alpha/beta/gamma MAPK [nucleoplasm]
Physical Entity
Activity
Orthologous Events
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Reviewed
Created