CDK2 phosphorylates RBBP8

Stable Identifier
R-HSA-5684096
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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CDK2, in complex with cyclin A (CCNA), phosphorylates RBBP8 (CtIP) on serine residue S327 and threonine residue T847. Residue T847 is conserved in the yeast ortholog of CtIP, Sae2, and phosphorylation of T847 increases CtIP activity in DNA end resection. Serine S327 phosphorylation enables CtIP to bind BRCA1 (Buis et al. 2012).

Literature References
PubMed ID Title Journal Year
22231403 Mre11 regulates CtIP-dependent double-strand break repair by interaction with CDK2

Stoneham, T, Buis, J, Spehalski, E, Ferguson, DO

Nat. Struct. Mol. Biol. 2012
Participants
Participates
Catalyst Activity

protein serine/threonine kinase activity of DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:CCNA:p-T160-CDK2:RBBP8 [nucleoplasm]

Orthologous Events
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